| 1 | GLUTAMATE RACEMASE (E.C.5.1.1.3) | 5.1.1.3 | Aquifex pyrophilus | 1b74 2jfw | 12 | 3–6 |
| 2 | beta-lactamase TEM (E.C.3.5.2.6) | 3.5.2.6 | Escherichia coli | 1nxy | 6 | 3–6 |
| 3 | NAD(P)H dehydrogenase [quinone] 1 (E.C.1.6.99.2) | 1.6.5.2 | Homo sapiens | 1kbo 5lva | 2 | 3 |
| 4 | COPPER-CONTAINING NITRITE REDUCTASE (E.C.1.7.2.1) | 1.7.2.1 | Achromobacter cycloclastes | 2bw4 | 7 | 3–7 |
| 5 | LYSOSOMAL PROTECTIVE PROTEIN (E.C.3.4.16.5) | 3.4.16.5 | Homo sapiens | 4ci9 | 4 | 3–5 |
| 6 | GLUTATHIONE REDUCTASE (E.C.1.6.4.2) OXIDIZED FORM COMPLEXED WITH RETRO-GSSG | 1.8.1.7 | Homo sapiens | 3djj 4gr1 | 14 | 3–7 |
| 7 | ISOCITRATE DEHYDROGENASE | 1.1.1.42 | Escherichia coli | 1ai3 1sjs | 4 | 3–4 |
| 8 | QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE, PHTHALIC ACID, 5-PHOSPHORIBOSYL-1-(BETA-METHYLENE) PYROPHOSPHATE, MANGANESE DIHYDRATE ION | 2.4.2.19 | Mycobacterium tuberculosis h37rv | 1qpr 5ayx | 8 | 3–5 |
| 9 | S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2 (E.C.2.5.1.6) | 2.5.1.6 | Homo sapiens | 1o93 5a1i 6sw5 6vcw 7bhw | 90 | 3–8 |
| 10 | BETA-HYDROXYDECANOYL THIOL ESTER DEHYDRASE, 2-DECENOYL N-ACETYL CYSTEAMINE | 5.3.3.14 | Escherichia coli | 1mka | 4 | 3–5 |
| 11 | PROBABLE ENDONUCLEASE 4 (E.C.3.1.21.2) | 3.1.21.2 | Thermotoga maritima msb8 | 1qtw 2x7v 3aam | 42 | 3–8 |
| 12 | ORNITHINE CARBAMOYLTRANSFERASE (E.C.2.1.3.3) | 2.1.3.3 | Homo sapiens | 1c9y 2ef0 | 12 | 3–6 |
| 14 | VANADIUM CHLOROPEROXIDASE (E.C.1.11.1.10) | 1.11.1.10 | Curvularia inaequalis | 1idq | 7 | 3–7 |
| 15 | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase (E.C.1.1.1.205,1.1.1.205) | 3.5.2.6 | Klebsiella pneumoniae | 6mgz | 10 | 3–8 |
| 16 | Lactamase_B domain-containing protein | 3.5.2.6 | Pontibacter korlensis | 5y6e 6xfr | 8 | 3–5 |
| 17 | Purine nucleoside phosphorylase (E.C.2.4.2.1) | 2.4.2.1 | Homo sapiens | 1a9r 1a9s 1i80 3d1v 3e0q 3k8q | 66 | 3–8 |
| 18 | L-ARGININE:GLYCINE AMIDINOTRANSFERASE, ORNITHINE | 2.1.4.1 | Homo sapiens | 3jdw | 4 | 3–5 |
| 20 | FLAVOCYTOCHROME C FUMARATE REDUCTASE (E.C.1.3.99.1) | 1.3.5.4 | Shewanella oneidensis | 1d4e 1m64 1qo8 | 21 | 3–7 |
| 21 | NAD-DEPENDENT MALIC ENZYME (E.C.1.1.1.40) | 1.1.1.38 | Homo sapiens | 1gz4 3nv9 6ags 6w2n | 40 | 3–8 |
| 22 | Serotonin N-acetyltransferase (E.C.2.3.1.87) | 2.3.1.87 | Ovis aries | 1kuy | 4 | 3–5 |
| 23 | PROTEIN (GLYCINE N-METHYLTRANSFERASE) (E.C.2.1.1.20) | 2.1.1.20 | Rattus norvegicus | 1d2c 1kia 2idj 5him | 16 | 3–5 |
| 24 | 4-CHLOROBENZOYL COENZYME A DEHALOGENASE, 4-HYDROXYBENZOYL COENZYME A, 1,2-ETHANEDIOL | 3.8.1.7 | Pseudomonas sp. cbs3 | 1nzy | 6 | 3–6 |
| 25 | N-CARBAMOYLSARCOSINE AMIDOHYDROLASE (E.C.3.5.1.59) | 3.5.1.59 | Arthrobacter sp. | 1nba | 4 | 3–5 |
| 26 | 1-phosphatidylinositol phosphodiesterase (E.C.4.6.1.13) | 4.6.1.13 | Staphylococcus aureus | 4rv3 | 4 | 3–5 |
| 27 | PHOSPHOLIPASE C (E.C.3.1.4.3) | 3.1.4.3 | Clostridium perfringens | 1qmd 2wxu | 20 | 3–8 |
| 28 | PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1, INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHATE | 3.1.4.11 | Rattus norvegicus | 1djw | 6 | 3–6 |
| 29 | CRYSTAL STRUCTURE OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE WITH THE INHIBITOR DON COVALENTLY BOUND IN THE ACTIVE SITE (E.C.3.5.1.38) | 3.5.1.38 | Pseudomonas sp. | 1agx 1djp | 8 | 3–6 |
| 30 | FORMATE ACETYLTRANSFERASE 1 (E.C.2.3.1.54) | 2.3.1.54 | Escherichia coli | 1h16 | 2 | 3–4 |
| 31 | THYMIDYLATE SYNTHASE, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE | 2.1.1.45 | Lactobacillus casei | 1nje | 6 | 3–6 |
| 32 | PROTEIN (LACTOYLGLUTATHIONE LYASE) (4.4.1.5) | 4.4.1.5 | Homo sapiens | 1qin | 2 | 3–4 |
| 33 | Methylmalonyl-CoA epimerase | None | Streptomyces coelicolor | 6wfh | 4 | 3–5 |
| 34 | CATECHOL 2,3-DIOXYGENASE | 1.13.11.2 | Pseudomonas putida | 1mpy | 6 | 3–6 |
| 35 | Casein kinase II subunit alpha (E.C.2.7.11.1) | 2.7.11.1 | Homo sapiens | 6ehu | 4 | 3–5 |
| 36 | PROTEIN (L-2-HALOACID DEHALOGENASE) (3.8.1.2) | 3.8.1.2 | Xanthobacter autotrophicus | 1qq5 | 11 | 3–8 |
| 37 | CYCLOOXYGENASE-2, PROTOPORPHYRIN IX CONTAINING FE, 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE | 1.14.99.1 | Mus musculus | 1ddx 6cox | 14 | 3–7 |
| 38 | GTP cyclohydrolase I (E.C.3.5.4.16) | 3.5.4.16 | Thermus thermophilus | 1wm9 | 7 | 3–7 |
| 39 | RIBONUCLEOSIDE HYDROLASE (RihA) PROTEIN | 3.2.-.- | Shewanella loihica | 1mas 4wr2 | 20 | 3–8 |
| 40 | PHOSPHOGLYCERATE KINASE 1 (E.C.2.7.2.3) | 2.7.2.3 | Homo sapiens | 2cun 2x15 2xe7 | 6 | 3–4 |
| 41 | Actin, gamma-enteric smooth muscle, Deoxyribonuclease-1 (E.C.3.1.21.1) | 3.1.21.1 | Bos taurus | 3w3d 4awn | 14 | 3–7 |
| 42 | NUCLEASE (E.C.3.1.30.2) | 3.1.30.2 | Serratia marcescens | 1ql0 1smn | 8 | 3–5 |
| 43 | PURPLE ACID PHOSPHATASE | 3.1.3.2 | Phaseolus vulgaris | 1kbp | 11 | 3–8 |
| 44 | ALKALINE PHOSPHATASE (E.C.3.1.3.1) | 3.1.3.1 | Escherichia coli | 1ew9 3bdh | 30 | 3–8 |
| 45 | CYCLODEXTRIN GLYCOSYLTRANSFERASE | 2.4.1.19 | Bacillus circulans | 2cxg | 4 | 3–5 |
| 46 | ADENINE-N6-DNA-METHYLTRANSFERASE TAQI, ADENOSYL-ORNITHINE | 2.1.1.72 | Thermus aquaticus | 1aqj | 2 | 3–4 |
| 47 | Protein-tyrosine-phosphatase (E.C.3.1.3.48) | 3.1.3.48 | Yersinia pestis | 3u96 5h08 6dr1 6dt6 7l0i | 35 | 3–7 |
| 48 | Hypoxanthine-guanine phosphoribosyltransferase (E.C.2.4.2.8) | 2.4.2.8 | Homo sapiens | 3ggj 3h83 6apv | 16 | 3–5 |
| 50 | OROTIDINE 5'-PHOSPHATE DECARBOXYLASE (E.C.4.1.1.23) | 4.1.1.23 | Escherichia coli | 1jjk 2yyu | 12 | 3–6 |
| 51 | Phosphoenolpyruvate carboxykinase [ATP] (E.C.4.1.1.49) | 4.1.1.49 | Escherichia coli | 1oen 1os1 | 20 | 3–8 |
| 52 | PROTEIN (FRUCTOSE-BISPHOSPHATE ALDOLASE II) (4.1.2.13) | 4.1.2.13 | Escherichia coli | 1b57 3q94 7ncc | 18 | 3–6 |
| 54 | 3-DEHYDROQUINATE DEHYDRATASE | 4.2.1.10 | Salmonella typhi | 1qfe | 1 | 3 |