Pattern screening for de novo protein
Safety and compliance screening for structural motifs and surface fingerprints against a curated library of concerns.
AI generated proteins
Evading all legacy biosecurity screenings
Tools like proteinMPNN and RFdiffusion can easily design a de novo protein (yellow) mimicking any natural patterns, including the concerning ones like an Ebola protein (blue). They share only 18% sequence similarity and therefore pass all sequence-based security screening.
- De novo protein
- Ebola nucleoprotein
Solution
A pattern-based screening pipeline
Sequence pattern
Hidden Markov models (HMMs) sequence search against regulated genes and pathogens.
Structure pattern
Fast structure search against catalytic and interacting motifs from known toxic proteins.
Surface pattern
Recognising and comparing patterns in protein surfaces including geometric and chemical features.
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